DDIT3 gene is associated with which sarcoma?

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Multiple Choice

DDIT3 gene is associated with which sarcoma?

Explanation:
DDIT3 rearrangements are a hallmark of myxoid/round cell liposarcoma. In this tumor, a chromosomal translocation typically fuses DDIT3 (also known as CHOP) with FUS (t(12;16)(q13;p11)), and less commonly with EWSR1 (t(12;22)(q13;q12)). The fusion protein alters transcription and drives the characteristic myxoid and round cell features, making this molecular change a key diagnostic marker detectable by FISH or RT-PCR. Other sarcomas listed do not harbor this DDIT3 rearrangement, so the association points to the myxoid/round cell liposarcoma.

DDIT3 rearrangements are a hallmark of myxoid/round cell liposarcoma. In this tumor, a chromosomal translocation typically fuses DDIT3 (also known as CHOP) with FUS (t(12;16)(q13;p11)), and less commonly with EWSR1 (t(12;22)(q13;q12)). The fusion protein alters transcription and drives the characteristic myxoid and round cell features, making this molecular change a key diagnostic marker detectable by FISH or RT-PCR. Other sarcomas listed do not harbor this DDIT3 rearrangement, so the association points to the myxoid/round cell liposarcoma.

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