EWSR1 gene is associated with which tumor?

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Multiple Choice

EWSR1 gene is associated with which tumor?

Explanation:
EWSR1 rearrangements, especially the EWSR1-FLI1 fusion from a t(11;22)(q24;q12), are a defining feature of Ewing sarcoma. This chimeric transcription factor drives the abnormal gene expression that underlies the characteristic small round blue cell appearance of the tumor. In practice, detecting the EWSR1 rearrangement by FISH or RT-PCR strongly supports a diagnosis of Ewing sarcoma when the histology and clinical picture fit. The other tumors listed do not characteristicly hinge on EWSR1 fusions, though note that EWSR1 can be involved in other neoplasms with different partner genes. Therefore, Ewing sarcoma is the tumor most associated with EWSR1.

EWSR1 rearrangements, especially the EWSR1-FLI1 fusion from a t(11;22)(q24;q12), are a defining feature of Ewing sarcoma. This chimeric transcription factor drives the abnormal gene expression that underlies the characteristic small round blue cell appearance of the tumor. In practice, detecting the EWSR1 rearrangement by FISH or RT-PCR strongly supports a diagnosis of Ewing sarcoma when the histology and clinical picture fit. The other tumors listed do not characteristicly hinge on EWSR1 fusions, though note that EWSR1 can be involved in other neoplasms with different partner genes. Therefore, Ewing sarcoma is the tumor most associated with EWSR1.

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