Markers used in the diagnosis of gastrointestinal stromal tumors (GIST) include which of the following?

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Multiple Choice

Markers used in the diagnosis of gastrointestinal stromal tumors (GIST) include which of the following?

Explanation:
In diagnosing GIST, the key idea is that these tumors characteristically express CD117, the receptor tyrosine kinase c-KIT. This marker is positive in the majority of GISTs and is essential for confirming the diagnosis and guiding therapy with drugs like imatinib that target c-KIT. The other markers point to different cell lineages: CD3 marks T lymphocytes, CK7 labels certain epithelial cells, and CD31 identifies endothelial cells, none of which define GIST. (DOG1 is another helpful marker sometimes positive in GISTs, but CD117 remains a primary and widely used diagnostic marker.)

In diagnosing GIST, the key idea is that these tumors characteristically express CD117, the receptor tyrosine kinase c-KIT. This marker is positive in the majority of GISTs and is essential for confirming the diagnosis and guiding therapy with drugs like imatinib that target c-KIT. The other markers point to different cell lineages: CD3 marks T lymphocytes, CK7 labels certain epithelial cells, and CD31 identifies endothelial cells, none of which define GIST. (DOG1 is another helpful marker sometimes positive in GISTs, but CD117 remains a primary and widely used diagnostic marker.)

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