SYT gene is associated with which soft tissue tumor?

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Multiple Choice

SYT gene is associated with which soft tissue tumor?

Explanation:
Gene fusions are powerful diagnostic markers in soft tissue tumors. The SYT gene (also known as SS18) fuses with members of the SSX family (SSX1, SSX2, or SSX4) through a t(X;18) translocation. The resulting SS18-SSX fusion protein drives aberrant transcription and is the defining molecular event of synovial sarcoma. This fusion is a key clue that distinguishes synovial sarcoma from other soft tissue sarcomas, which have different genetic alterations—for example, Ewing sarcoma with EWSR1 fusions, liposarcoma with MDM2 amplification or FUS-DDIT3 in myxoid subtypes, and rhabdomyosarcoma with PAX3/7-FOXO1 fusions.

Gene fusions are powerful diagnostic markers in soft tissue tumors. The SYT gene (also known as SS18) fuses with members of the SSX family (SSX1, SSX2, or SSX4) through a t(X;18) translocation. The resulting SS18-SSX fusion protein drives aberrant transcription and is the defining molecular event of synovial sarcoma. This fusion is a key clue that distinguishes synovial sarcoma from other soft tissue sarcomas, which have different genetic alterations—for example, Ewing sarcoma with EWSR1 fusions, liposarcoma with MDM2 amplification or FUS-DDIT3 in myxoid subtypes, and rhabdomyosarcoma with PAX3/7-FOXO1 fusions.

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