Which gene is commonly rearranged in synovial sarcoma?

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Multiple Choice

Which gene is commonly rearranged in synovial sarcoma?

Explanation:
Synovial sarcoma is classically driven by a chromosomal translocation that fuses the SYT gene (also called SS18) on chromosome 18 with an SSX gene (SSX1 or SSX2). This SYT-SSX fusion is the defining molecular event and is routinely sought by FISH or RT-PCR to confirm the diagnosis. The other genes listed are associated with different tumors: EWSR1 rearrangements with Ewing sarcoma, FOXO1A fusions with alveolar rhabdomyosarcoma, and DDIT3 rearrangements with myxoid liposarcoma. Thus, SYT is the gene commonly rearranged in synovial sarcoma.

Synovial sarcoma is classically driven by a chromosomal translocation that fuses the SYT gene (also called SS18) on chromosome 18 with an SSX gene (SSX1 or SSX2). This SYT-SSX fusion is the defining molecular event and is routinely sought by FISH or RT-PCR to confirm the diagnosis. The other genes listed are associated with different tumors: EWSR1 rearrangements with Ewing sarcoma, FOXO1A fusions with alveolar rhabdomyosarcoma, and DDIT3 rearrangements with myxoid liposarcoma. Thus, SYT is the gene commonly rearranged in synovial sarcoma.

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