Which immunophenotype best describes Chronic Lymphocytic Leukemia (CLL) among the listed markers?

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Multiple Choice

Which immunophenotype best describes Chronic Lymphocytic Leukemia (CLL) among the listed markers?

Explanation:
CLL is characterized by mature B cells that aberrantly express CD5 together with the B-cell markers CD20 (usually dim) and CD23, while being negative for Cyclin D1 and CD3. The combination CD5+, CD23+, CD20 positive (dim), Cyclin D1-, CD3- fits this pattern. The presence of Cyclin D1 would point toward mantle cell lymphoma, and lack of CD5 or CD23 would argue against CLL. So the best match is the profile with CD5 and CD23 positivity among B-cell markers, CD20 positive, Cyclin D1 negative, and CD3 negative.

CLL is characterized by mature B cells that aberrantly express CD5 together with the B-cell markers CD20 (usually dim) and CD23, while being negative for Cyclin D1 and CD3. The combination CD5+, CD23+, CD20 positive (dim), Cyclin D1-, CD3- fits this pattern. The presence of Cyclin D1 would point toward mantle cell lymphoma, and lack of CD5 or CD23 would argue against CLL. So the best match is the profile with CD5 and CD23 positivity among B-cell markers, CD20 positive, Cyclin D1 negative, and CD3 negative.

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