Which marker profile is characteristic of Hairy Cell Leukemia in terms of CD5 expression?

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Multiple Choice

Which marker profile is characteristic of Hairy Cell Leukemia in terms of CD5 expression?

Explanation:
Hairy Cell Leukemia has a distinctive immunophenotype in which CD5 is not expressed. In practice, HCL is characteristically CD11c+, CD25+, and CD103+, with CD19/CD20 and HLA-DR also often positive, and it is typically negative for CD5. This absence of CD5 helps distinguish HCL from other CD5-positive B-cell neoplasms such as CLL/SLL and mantle cell lymphoma. So, in terms of CD5 expression, the key point is that CD5 is not present in hairy cell leukemia, while the other markers—CD11c, CD25, and CD103—define its positive profile.

Hairy Cell Leukemia has a distinctive immunophenotype in which CD5 is not expressed. In practice, HCL is characteristically CD11c+, CD25+, and CD103+, with CD19/CD20 and HLA-DR also often positive, and it is typically negative for CD5. This absence of CD5 helps distinguish HCL from other CD5-positive B-cell neoplasms such as CLL/SLL and mantle cell lymphoma. So, in terms of CD5 expression, the key point is that CD5 is not present in hairy cell leukemia, while the other markers—CD11c, CD25, and CD103—define its positive profile.

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