Which microorganism is detected by Epstein-Barr Virus–encoded RNA (EBER) in situ hybridization?

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Multiple Choice

Which microorganism is detected by Epstein-Barr Virus–encoded RNA (EBER) in situ hybridization?

Explanation:
EBER in situ hybridization targets the RNA transcripts encoded by Epstein-Barr Virus, specifically EBER1 and EBER2. These small RNAs are abundantly expressed in cells with latent EBV infection, so using probes that bind to them lets you visualize EBV-infected cells directly in tissue sections. This makes EBER ISH a sensitive and specific method for confirming EBV involvement in tumors and other lesions, helping distinguish EBV-associated processes from others. The microorganism detected is Epstein-Barr Virus. The other options are not identified by EBER probes—H. pylori is a bacterium, and CMV and HSV are different viruses that would require other tests for detection.

EBER in situ hybridization targets the RNA transcripts encoded by Epstein-Barr Virus, specifically EBER1 and EBER2. These small RNAs are abundantly expressed in cells with latent EBV infection, so using probes that bind to them lets you visualize EBV-infected cells directly in tissue sections. This makes EBER ISH a sensitive and specific method for confirming EBV involvement in tumors and other lesions, helping distinguish EBV-associated processes from others. The microorganism detected is Epstein-Barr Virus. The other options are not identified by EBER probes—H. pylori is a bacterium, and CMV and HSV are different viruses that would require other tests for detection.

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